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anti-MPO (human), Rabbit Monoclonal (RM407)

Research Use Only
REV-31-1293-00
RevMAb Biosciences
ApplicationsImmunoHistoChemistry, Western Blot
Product group Antibodies
ReactivityHuman
TargetMPO
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-MPO (human), Rabbit Monoclonal (RM407)
  • Delivery Days Customer
    5
  • Applications
    ImmunoHistoChemistry, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM407
  • Gene ID4353
  • Target name
    MPO
  • Target description
    myeloperoxidase
  • Target synonyms
    myeloperoxidase
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains and two unglycosylated beta chains. Traditionally, myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities such as periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Myeloperoxidase also participates in the initiation and progression of cardiovascular disease and is a promising cardiac markers. Myeloperoxidase possesses potent proinflammatory properties and may contribute directly to tissue injury. Myeloperoxidase is part of the host defense system of polymorphonuclear leukocytes and myeloperoxidase is responsible for microbicidal activity against a wide range of organisms. In stimulated PMN (polymorphonuclear leukocytes), MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Myeloperoxidase immunostaining is important in the diagnosis of myeloid sarcoma, contrasting with the negative staining of lymphomas. - Recombinant Antibody. This antibody reacts to human to MPO. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains and two unglycosylated beta chains. Traditionally, myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities such as periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Myeloperoxidase also participates in the initiation and progression of cardiovascular disease and is a promising cardiac markers. Myeloperoxidase possesses potent proinflammatory properties and may contribute directly to tissue injury. Myeloperoxidase is part of the host defense system of polymorphonuclear leukocytes and myeloperoxidase is responsible for microbicidal activity against a wide range of organisms. In stimulated PMN (polymorphonuclear leukocytes), MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Myeloperoxidase immunostaining is important in the diagnosis of myeloid sarcoma, contrasting with the negative staining of lymphomas.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203