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Immunohistochemical staining of formalin fixed and paraffin embedded human Rhabdomyosarcoma section using anti-MyoD1 rabbit monoclonal antibody (Clone RM369) at a 1:1000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human Rhabdomyosarcoma section using anti-MyoD1 rabbit monoclonal antibody (Clone RM369) at a 1:1000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human Rhabdomyosarcoma section using anti-MyoD1 rabbit monoclonal antibody (Clone RM369) at a 1:1000 dilution.

anti-MyoD1 (human), Rabbit Monoclonal (RM369)

REV-31-1255-00
RevMAb Biosciences
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
TargetMYOD1
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-MyoD1 (human), Rabbit Monoclonal (RM369)
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM369
  • Gene ID4654
  • Target name
    MYOD1
  • Target description
    myogenic differentiation 1
  • Target synonyms
    bHLHc1; class C basic helix-loop-helix protein 1; MYF3; myf-3; myoblast determination protein 1; MYOD; MYODRIF; myogenic factor 3; PUM
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP15172
  • Protein Name
    Myoblast determination protein 1
  • Scientific Description
    MyoD (MyoD1; Myoblast Determination Protein 1) plays a major role in regulating muscle differentiation. It belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members include MyoD1, Myf5, myogenin and MRF4 (Myf6). MyoD is one of the earliest markers of myogenic commitment. MyoD is expressed at extremely low and essentially undetectable levels in quiescent satellite cells, but expression of MyoD is activated in response to exercise or muscle tissue damage. High MyoD expression represses cell renewal, promotes terminal differentiation and can induce apoptosis. The function of MyoD in development is to commit mesoderm cells to a skeletal myoblast lineage, and then to regulate that continued state. MyoD may also regulate muscle repair. MyoD mRNA levels are also reported to be elevated in aging skeletal muscle. One of the main actions of MyoD is to remove cells from the cell cycle (halt proliferation for terminal cell cycle arrest in differentiated myocytes) by enhancing the transcription of p21 and myogenin. MyoD, as a transcription factor, can also direct chromatin remodelling through binding to a DNA motif known as the E-box. - Recombinant Antibody. This antibody reacts to human, mouse, and rat MyoD1 (Myoblast determination protein 1) . Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. MyoD (MyoD1; Myoblast Determination Protein 1) plays a major role in regulating muscle differentiation. It belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members include MyoD1, Myf5, myogenin and MRF4 (Myf6). MyoD is one of the earliest markers of myogenic commitment. MyoD is expressed at extremely low and essentially undetectable levels in quiescent satellite cells, but expression of MyoD is activated in response to exercise or muscle tissue damage. High MyoD expression represses cell renewal, promotes terminal differentiation and can induce apoptosis. The function of MyoD in development is to commit mesoderm cells to a skeletal myoblast lineage, and then to regulate that continued state. MyoD may also regulate muscle repair. MyoD mRNA levels are also reported to be elevated in aging skeletal muscle. One of the main actions of MyoD is to remove cells from the cell cycle (halt proliferation for terminal cell cycle arrest in differentiated myocytes) by enhancing the transcription of p21 and myogenin. MyoD, as a transcription factor, can also direct chromatin remodelling through binding to a DNA motif known as the E-box.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203

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