Anti-NKG2A [Z199]

Absolute Antibody

Anti-NKG2A [Z199]

9

This antibody was reported to be a non-competitive antagonist of human CD94/NKG2A receptor expressed on lymphocytes, since it inhibited the function of CD94/NKG2A. Z199 can block the function of human CD94/NKG2A, and specifically induce killing of cells by CD94/NKG2A-restricted lymphocytes in a concentration-dependent fashion (US8796427). This antibody was used to study the covalent interactions between CD94 and NKG2A, which together form the inhibitory natural killer cell receptor (PMID: 9045931). This antibody was used to study the binding interactions of HLA-E (wild-type) tetramer to CD94/NKG2A or CD94/NKG2C expressing cells by flow cytometry (PMID: 14971033). This antibody was used to test the cytotoxic activity of NKL cells against tumor cells. NKL cells were tested for their ability to lyse the indicated targets in a 51Cr release assay, this antibody was found to enhance NK lysis (PMID: 21969815).

Flow Cytometry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

Z199

KLRC1

killer cell lectin like receptor C1

CD159A, NKG2, NKG2A, NKG2-A/NKG2-B type II integral membrane protein, C-lectin type II protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-1/B activating NK receptor, NKG2-A/B type II integral membrane protein, NKG2-A/B-activating NK receptor, killer cell lectin-like receptor subfamily C, member 1, natural killer cell lectin, natural killer group protein 2

Rabbit

IgG

NKG2-A/NKG2-B type II integral membrane protein

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.

-20°C,2°C to 8°C

12352203