Anti-Notch 4 [GLA-S4F18]

Absolute Antibody

Anti-Notch 4 [GLA-S4F18]

7

The original human IgG1, GLA-S4F18 antibody binds human and mouse notch 4 with an EC50 of 0.09 nM and 0.11 nM respectively as measured by direct ELISA. The binding of this antibody to surface expressed notch 4 was determined by flow cytometry. This antibody was reported to significantly delay tumor regrowth when administered in combination with carboplatin in an ovarian xenograft tumor model. When used in combination with cisplatin it delayed tumor regrowth in ovarian PDX models. It also resulted in reduction in cancer stem cells (CSC) present in tumors when treated with GLA-S4F18 alone or in combination with abraxane (WO2018039107).

ELISA

ELISA;

Research Use Only

Monoclonal

GLA-S4F18

NOTCH4

notch receptor 4

INT3; neurogenic locus notch homolog protein 4; notch 4; Notch homolog 4

Human

IgG1

Neurogenic locus notch homolog protein 4

Human, mouse

The original antibody was isolated from a phage display library generated from a non immunized donor and panning against human and mouse Notch4-negative regulatory region or NRR antigens.

-20°C,2°C to 8°C

12352203