Anti-osteopontin [hu1A12]

Absolute Antibody

Anti-osteopontin [hu1A12]

9

hu1A12 suppreses MDA-MB-435S (highly metastatic human breast cancer cell line) cell migration (evaluated by scratch-wound healing) and also inhibits cell adhesion of MDA-MB-435S cells to human OPN. hu1A12 also inhibits the anti-apoptotic and pro-survival functions of OPN possibly through upregulating Bax, downregulating Bcl-2, and blocking the activation of NF-kappaB. hu1A12 also has been shown to suppress primary breast tumour growth in humans through in vivo studies. This antibody has also been used in ELISA, IHC and SPR studies.

ELISA, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

hu1A12

SPP1

secreted phosphoprotein 1

BNSP; BSPI; early T-lymphocyte activation 1; ETA-1; nephropontin; OPN; osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein 1 variant 6; SPP1/CALPHA1 fusion; urinary stone protein; uropontin

Mouse

IgG1

Osteopontin

-20°C,2°C to 8°C

12352203