Anti-PCSK9 [mAb1]

Absolute Antibody

Anti-PCSK9 [mAb1]

9

This antibody binds module 1 of the C-terminal domain (CTD) of PCSK9. It was reported to interact with amino acid residues R469, R496 and F515 of the human PCSK9. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease enzyme encoded by

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. This antibody blocks access to an area bearing several naturally occurring gain-of-function and loss-of-function mutations. This antibody does not completely inhibit binding of PCSK9 to epidermal growth factor-like repeat A, it partially reverses PCSK9-induced reduction of the LDLR and LDL cholesterol uptake in a cellular assay. This antibody was also reported to be effective in lowering serum levels of LDL cholesterol in cynomolgus monkeys in vivo (PMID: 24252255).

Functional Assay, ELISA

Research Use Only

Monoclonal

mAb1

PCSK9

proprotein convertase subtilisin/kexin type 9

convertase subtilisin/kexin type 9 preproprotein; FH3; FHCL3; HCHOLA3; LDLCQ1; NARC1; NARC-1; neural apoptosis regulated convertase 1; PC9; proprotein convertase subtilisin/kexin type 9; subtilisin/kexin-like protease PC9

Rabbit

IgG

Proprotein convertase subtilisin/kexin type 9

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human, Monkey

-20°C,2°C to 8°C

12352203