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Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-Phospho-Acetyl CoA Carboxylase (Ser79) Rabbit Monoclonal Antibody (clone RM270) at a 1:5000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-Phospho-Acetyl CoA Carboxylase (Ser79) Rabbit Monoclonal Antibody (clone RM270) at a 1:5000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-Phospho-Acetyl CoA Carboxylase (Ser79) Rabbit Monoclonal Antibody (clone RM270) at a 1:5000 dilution.

anti-Phospho Acetyl CoA Carboxylase (S79) (human), Rabbit Monoclonal (RM270)

Research Use Only
REV-31-1151-00
RevMAb Biosciences
ApplicationsImmunoHistoChemistry, Western Blot
Product group Antibodies
ReactivityHuman
TargetACACA
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-Phospho Acetyl CoA Carboxylase (S79) (human), Rabbit Monoclonal (RM270)
  • Delivery Days Customer
    5
  • Applications
    ImmunoHistoChemistry, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM270
  • Gene ID31
  • Target name
    ACACA
  • Target description
    acetyl-CoA carboxylase alpha
  • Target synonyms
    ACAC; ACACAD; ACC; ACC1; ACCA; ACC-alpha; acetyl-CoA carboxylase 1; acetyl-Coenzyme A carboxylase alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). The function of ACC is to regulate the metabolism of fatty acids. When the enzyme is active, the product, malonyl-CoA, is produced which is a building block for new fatty acids and can inhibit the transfer of the fatty acyl group from acyl CoA to carnitine with carnitine acyltransferase, which inhibits the beta-oxidation of fatty acids in the mitochondria. There are two ACC forms, alpha (ACC1) and beta (ACC2), encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC. - Recombinant Antibody. This antibody reacts to human Acetyl CoA Carboxylase (ACC1) only when phosphorylated at Ser79. There is no cross-reactivity to Acetyl CoA Carboxylase without phosphorylation at Ser79. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). The function of ACC is to regulate the metabolism of fatty acids. When the enzyme is active, the product, malonyl-CoA, is produced which is a building block for new fatty acids and can inhibit the transfer of the fatty acyl group from acyl CoA to carnitine with carnitine acyltransferase, which inhibits the beta-oxidation of fatty acids in the mitochondria. There are two ACC forms, alpha (ACC1) and beta (ACC2), encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203