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anti-Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198), Rabbit Monoclonal (RM454)

anti-Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198), Rabbit Monoclonal (RM454)

Research Use Only
REV-31-1346-00
RevMAb Biosciences
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetAURKA
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198), Rabbit Monoclonal (RM454)
  • Delivery Days Customer
    5
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM454
  • Gene ID6790
  • Target name
    AURKA
  • Target description
    aurora kinase A
  • Target synonyms
    AIK; ARK1; AURA; aurora 2; aurora kinase A; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; BTAK; PPP1R47; protein phosphatase 1, regulatory subunit 47; serine/threonine protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; STK15; STK6; STK7
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression. Aurora A is a 46 kDa protein that plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. Aurora B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. - Recombinant Antibody. This antibody reacts to human Aurora A/B/C only when phosphorylated at either Thr288, Thr232 or Thr198 respectively. There is no cross-reactivity to Aurora A/B/C that is not phosphorylated. Applications: IHC, WB. Clone: RM454. Isotype: Rabbit IgG. Formulation: Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression. Aurora A is a 46 kDa protein that plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. Aurora B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203