anti-Pyruvate Carboxylase antibody

Arigo Biolaboratories

anti-Pyruvate Carboxylase antibody

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

PC

pyruvate carboxylase

PCB, pyruvate carboxylase, mitochondrial, pyruvic carboxylase

Rabbit

IgG

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5 UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

-20°C

12352203