anti-RPE65 antibody

Arigo Biolaboratories

anti-RPE65 antibody

23

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

RPE65

retinoid isomerohydrolase RPE65

BCO3, LCA2, RP20, mRPE65, p63, rd12, sRPE65, retinoid isomerohydrolase, BCO family, member 3, RBP-binding membrane protein, RPE65, retinoid isomerohydrolase, all-trans-retinyl-palmitate hydrolase, lutein isomerase, meso-zeaxanthin isomerase, retinal pigment epithelium specific protein 65, retinal pigment epithelium-specific 65 kDa protein, retinal pigment epithelium-specific protein 65kDa, retinitis pigmentosa 20 (autosomal recessive), retinol isomerase

Rabbit

IgG

This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]

-20°C

12352203