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Anti-Sclerostin [AbD09097]

AB03705-10.0
Absolute Antibody
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
TargetSOST
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-Sclerostin [AbD09097]
  • Delivery Days Customer
    9
  • Application Supplier Note
    The binding reactivity of this antibody for mouse sclerostin was tested using ELISA. This antibody binds mouse and human sclerostin with a binding affinity of Kd= 46nM and Kd=260 nM respectively. This antibody efficiently neutralizes sclerostins Wnt inhibitory activity. In vitro interaction analysis using sclerostin variants revealed that this neutralizing Fab binds to sclerostins flexible second loop, which has been shown to harbor the LRP5/6 binding motif (PMID: 27558933).
  • Applications
    ELISA, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    AbD09097
  • Gene ID50964
  • Target name
    SOST
  • Target description
    sclerostin
  • Target synonyms
    CDD; DAND6; sclerostin; SOST1; VBCH
  • Host
    Human
  • Isotype
    IgG1
  • Protein IDQ99P68
  • Protein Name
    Sclerostin
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

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