Anti-SERT [8B6]

Absolute Antibody

Anti-SERT [8B6]

7

The 8B6 Fab binds to extracellular loops 2 and 4 of hSERT, as shown by crystallography (Coleman et al, 2016).

The 8B6 Fab fragment was crystallised in complex with human SERT to aid structure determination (Coleman et al, 2016).

Other Application

Crystallisation

Research Use Only

Monoclonal

8B6

SLC6A4

solute carrier family 6 member 4

5HT transporter; 5HTT; 5-HTT; 5-HTTLPR; 5-hydroxytryptamine (serotonin) transporter; hSERT; HTT; Na+/Cl- dependent serotonin transporter; OCD1; serotonin transporter 1; SERT; SERT1; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Human

IgG4

Sodium-dependent serotonin transporter

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

8B6 was produced by immunising SERT KO mice with residues 73-616 of wildtype human SERT. Hybridomas were generated using established protocols.

-20°C,2°C to 8°C

12352203