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ProductsBack/anti-Sox2 Rabbit Monoclonal (RM427)
anti-Sox2 Rabbit Monoclonal (RM427)

anti-Sox2 Rabbit Monoclonal (RM427)

Research Use Only
REV-31-1314-00
RevMAb Biosciences
ApplicationsWestern Blot, ImmunoHistoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetSOX2
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-SOX2 (human), Rabbit Monoclonal (RM427)
  • Delivery Days Customer
    5
  • Antibody Specificity
    RM427 reacts to human SOX2.
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM427
  • Formulation
    Liquid
  • Gene ID6657
  • Target name
    SOX2
  • Target description
    SRY-box transcription factor 2
  • Target synonyms
    ANOP3; MCOPS3; sex determining region Y-box 2; SRY (sex determining region Y)-box 2; SRY-box 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP48431
  • Protein Name
    Transcription factor SOX-2
  • Scientific Description
    Recombinant Antibody. This antibody RM427 reacts to human SOX2. Application: IHC, WB . Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. SOX2 is the most studied member of SRY-related box transcription factor family. It binds to target genes through its highly conserved HMG box domain. Inactivation of the SOX2 gene causes lethality during embryonic development. SOX2 knockdown in embryonic stem cells results in their differentiation. Co-expression of SOX with OCT4, MYC, and KLF4 is sufficient to reprogram somatic cells to induced pluripotent stem cells (iPSCs), which exert similar characteristics as natural pluripotent stem cells. These findings indicate that SOX2 is crucial for the self-renewal and pluripotency of embryonic stem cells. In addition, over-expression of SOX2 has been found in various types of malignant cancer. Knockdown of SOX2 results in cell cycle arrest by downregulating cyclin D1 and inhibition of tumor cell proliferation, suggesting that SOX2 is involved in activating genes associated with tumor progression. - SOX2 is the most studied member of SRY-related box transcription factor family. It binds to target genes through its highly conserved HMG box domain. Inactivation of the SOX2 gene causes lethality during embryonic development. SOX2 knockdown in embryonic stem cells results in their differentiation. Co-expression of SOX with OCT4, MYC, and KLF4 is sufficient to reprogram somatic cells to induced pluripotent stem cells (iPSCs), which exert similar characteristics as natural pluripotent stem cells. These findings indicate that SOX2 is crucial for the self-renewal and pluripotency of embryonic stem cells. In addition, over-expression of SOX2 has been found in various types of malignant cancer. Knockdown of SOX2 results in cell cycle arrest by downregulating cyclin D1 and inhibition of tumor cell proliferation, suggesting that SOX2 is involved in activating genes associated with tumor progression.
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203