Anti-TdT Antibody

HUABIO

Anti-TdT Antibody

7

Western Blot

WB

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

DNTT

DNA nucleotidylexotransferase

TDT, DNA nucleotidylexotransferase, nucleosidetriphosphate:DNA deoxynucleotidylexotransferase, terminal addition enzyme, terminal deoxynucleotidyltransferase, terminal deoxyribonucleotidyltransferase, terminal transferase

Rabbit

IgG

DNA nucleotidylexotransferase

Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. The nuclear enzyme TdT plays a critical role in generating immune receptor diversity. During rearrangement of Ig and TCR V region genes, TdT catalyzes the addition of N nucleotides without a DNA template to V-D and D-J junctions in both Ig and TCR as well as the V-J junctions in the TCR (1-3). During the fetal and newborn period, TdT activity is absent, resulting in an N region-deficient Ag receptor repertoire significantly lacking in the diversity observed in the junctional regions of Igs and TCRs of adult animals

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161