Anti-TNFR2 [5E6]

Absolute Antibody

Anti-TNFR2 [5E6]

9

This antibody binds human TNFR2 (TNFRSF1B). TNFR2 is a receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha.

The binding characterization to human TNFR2 was done using ELISA. This antibody can effectively block the binding of TNFR2 with TNF alpha. The binding affinity of the original IgG antibody for human TNFR2 was determined using surface plasmon resonance and found to be Kd= 9.53 X 10^(-10) M. This antibody was also reported to show tumor inhibitory activity in b-HTNFR2 mice (colon cancer cells) (CN112480259).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

5E6

TNFRSF1B

TNF receptor superfamily member 1B

CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF-alpha receptor; soluble TNFR1B variant 1; TBPII; TNFBR; TNFR1B; TNFR2; TNF-R2; TNF-R75; TNFR80; TNF-RII; TNF-R-II; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor type II

Rabbit

IgG

Tumor necrosis factor receptor superfamily member 1B

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203