Anti-VEGFR2 [V1]

Absolute Antibody

Anti-VEGFR2 [V1]

9

This antibody is specific for the VEGFR2 protein. It shows no binding to individual domains 2-3, 1-3 and 1-4. VEGFR2 is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. It plays an essential role in the regulation

The human version of this antibody was tested by ELISA with different domains of VEGFR2 (WO2017004254). Furthermore, binding of the human version of this antibody to human umbilical vein endothelial cells was demostrated using flow cytometry (WO2017004254). After that, HUVEC tube formation assays were preformed using the human version of this antibody. This antibody did not show significant inhibition of tube formation (WO2017004254). Further, a matrigel plug assay was preformed using the human version of this antibody to asses its ability to inhibit angiogenesis in vivo (WO2017004254).

Functional Assay, Flow Cytometry, ELISA

Research Use Only

Monoclonal

V1

KDR

kinase insert domain receptor

CD309; fetal liver kinase-1; FLK1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; vascular endothelial growth factor receptor 2; VEGFR; VEGFR2

Human

IgG1

Vascular endothelial growth factor receptor 2

This reformatted human antibody was made using the variable domain sequences of the original Human IgG format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203