Anti-WDR5 Antibody

HUABIO

Anti-WDR5 Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot

WB,IF-Cell,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

WDR5

WD repeat domain 5

BIG-3, BIG3, CFAP89, SWD3, WD repeat-containing protein 5, BMP-2-induced gene 3 kb, BMP2-induced 3-kb gene protein, SWD3, Set1c WD40 repeat protein, homolog, cilia and flagella associated protein 89

Rabbit

IgG

WD repeat-containing protein 5

WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.

Human

Human

-20°C,2°C to 8°C

41116161