Anti-ZBTB48 Antibody

HUABIO

Anti-ZBTB48 Antibody

7

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ZBTB48

zinc finger and BTB domain containing 48

HKR3, TZAP, ZNF855, pp9964, zinc finger and BTB domain-containing protein 48, GLI-Kruppel family member HKR3, krueppel-related zinc finger protein 3, telomere zinc finger-associated protein, telomere-binding protein and transcriptional activator ZBTB48, telomeric zinc finger-associated protein, zinc finger protein 855

Rabbit

IgG

Zinc finger and BTB domain-containing protein 48

Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that directly binds to the double-stranded repeat sequence of telomeres. In humans it is encoded by the ZBTB48 gene. Loss of ZBTB48 has been shown to lead to telomere elongation both in cells with long and short telomeres. In addition, overexpression of ZBTB48 in cancer cells maintaining their telomeres based on the Alternative Lengthening of Telomeres (ALT) mechanism leads to trimming of telomeres. Beyond its telomeric function, ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1) and CDKN2A. ZBTB48 localizes to chromosome 1p36, a region that is frequently rearranged (leiomyoma & leukaemia) or deleted (neuroblastoma, melanoma, Merkel cell carcinoma, pheochromocytoma, and carcinomas of colon and breast) in different human cancers and therefore might be a putative tumour suppressor, but not without dispute.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161