Anti-ZO2 Antibody

HUABIO

Anti-ZO2 Antibody

7

ImmunoFluorescence, Western Blot

WB,IF-Cell

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TJP2

tight junction protein 2

C9DUPq21.11, DFNA51, DUP9q21.11, FHCA1, PFIC4, X104, ZO2, tight junction protein 2, Friedreich ataxia region gene X104 (tight junction protein ZO-2), zona occludens 2, zonula occludens protein 2

Rabbit

IgG

Tight junction protein 2

Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces. Zona occludens proteins ZO-1, -2, and -3 (also known as TJP1, 2, and 3) are peripheral membrane adaptor proteins that link junctional transmembrane proteins such as occludin and claudin to the actin cytoskeleton. ZO-1 and -2 are required for tight junction formation and function. In subconfluent proliferating cells, ZO-1 and ZO-2 have been shown to colocalize to the nucleus and play a role in transcriptional regulation, possibly through facilitating nuclear import/export of transcriptional regulators.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161