AP14145 (hydrochloride) [2387505-59-9]
HY-120355A
CAS Number2387505-59-9
Product group Chemicals
Estimated Purity98.3
Molecular Weight398.81
Overview
- SupplierMedChem Express
- Product NameAP14145 (hydrochloride) [2387505-59-9]
- Delivery Days Customer10
- CAS Number2387505-59-9
- CertificationResearch Use Only
- Estimated Purity98.3
- Molecular FormulaC18H18ClF3N4O
- Molecular Weight398.81
- Scientific DescriptionAP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 microM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF)[1][2].
- SMILESCC(NC1=C2C(N=C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O.[H]Cl
- Storage Instruction-20°C
- UNSPSC12352200
MSDS
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Product group Chemicals
CAS Number2387505-59-9
Molecular Weight398.81
- SizePrice
Product group Chemicals
AP14145 hydrochlorideORB1690932
CAS Number2387505-59-9
Estimated Purity98%
Molecular Weight398.81
- SizePrice