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AP14145 hydrochloride [2387505-59-9]

AP14145 hydrochloride [2387505-59-9]

T39963
TargetMol Chemicals
CAS Number2387505-59-9
Product group Chemicals
Molecular Weight398.81
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    AP14145 hydrochloride [2387505-59-9]
  • Delivery Days Customer
    16
  • CAS Number
    2387505-59-9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    AP14145 hydrochloride
  • Molecular Formula
    C18H18ClF3N4O
  • Molecular Weight
    398.81
  • Scientific Description
    AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 microM. Inhibition of AP14145 hydrochloride is highly influenced by S508 and A533 amino acids present in the channel. This compound effectively extends the atrial effective refractory period (AERP) in rats and exhibits antiarrhythmic properties in a Vernakalant-resistant porcine model of atrial fibrillation (AF).
  • Shelf life instruction
    3 years
  • SMILES
    Cl.C[C@@H](Nc1nc2cccc(NC(C)=O)c2[nH]1)c1cccc(c1)C(F)(F)F
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200