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AP14145 hydrochloride [2387505-59-9]
T39963
Overview
- SupplierTargetMol Chemicals
- Product NameAP14145 hydrochloride [2387505-59-9]
- Delivery Days Customer16
- CAS Number2387505-59-9
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameAP14145 hydrochloride
- Molecular FormulaC18H18ClF3N4O
- Molecular Weight398.81
- Scientific DescriptionAP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 microM. Inhibition of AP14145 hydrochloride is highly influenced by S508 and A533 amino acids present in the channel. This compound effectively extends the atrial effective refractory period (AERP) in rats and exhibits antiarrhythmic properties in a Vernakalant-resistant porcine model of atrial fibrillation (AF).
- Shelf life instruction3 years
- SMILESCl.C[C@@H](Nc1nc2cccc(NC(C)=O)c2[nH]1)c1cccc(c1)C(F)(F)F
- Storage Instruction-20°C
- UNSPSC12352200