APAF1 Polyclonal Antibody

Reddot Biotech

APAF1 Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.7 mg/ml

Unconjugated

APAF1

apoptotic peptidase activating factor 1

APAF-1; apoptotic protease-activating factor 1; CED4

Rabbit

IgG

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Human, Mouse, Rat

-20°C

12352203