Western blot analysis of extracts of various cell lines using ANAPC5 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of various cell lines using ANAPC5 Polyclonal Antibody at dilution of 1:1000.
APC5 Polyclonal Antibody
E-AB-61531
Product group Antibodies
Overview
- SupplierElabscience
- Product NameAPC5 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
- UNSPSC12352203