Apcin

MedChem Express

Apcin [300815-04-7]

9

300815-04-7

Research Use Only

99.71

C13H14Cl3N7O4

438.65

Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis [1] [2] [3] .

O=C(OCCN1C([N+]([O-])=O)=CN=C1C)NC(NC2=NC=CC=N2)C(Cl)(Cl)Cl

-20°C,2°C to 8°C

12352200