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Apcin

HY-110287
MedChem Express
CAS Number300815-04-7
DownloadMSDS
Product group Chemicals
Estimated Purity99.62
Molecular Weight438.65
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Apcin [300815-04-7]
  • Delivery Days Customer
    9
  • CAS Number
    300815-04-7
  • Certification
    Research Use Only
  • Estimated Purity
    99.62
  • Molecular Formula
    C13H14Cl3N7O4
  • Molecular Weight
    438.65
  • Scientific Description
    Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis[1][2][3].
  • SMILES
    O=C(OCCN1C([N+]([O-])=O)=CN=C1C)NC(NC2=NC=CC=N2)C(Cl)(Cl)Cl
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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