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API-1(NSC 177223)

ORB1089904
Biorbyt
CAS Number36707-00-3
Product group Chemicals
Molecular Weight337.2881
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Overview

  • Supplier
    Biorbyt
  • Product Name
    API-1(NSC 177223) [36707-00-3]
  • Delivery Days Customer
    10
  • CAS Number
    36707-00-3
  • Certification
    Research Use Only
  • Molecular Formula
    C13H15N5O6
  • Molecular Weight
    337.2881
  • Scientific Description
    API-1 is a potent Akt inhibitor, which induces GSK3-dependent, beta-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1.
  • SMILES
    OCC1C(O)C(O)C(O1)N2C3C(=C(N)N=CN=3)C(=O)C(C(N)=O)=C2
  • UNSPSC
    12352200

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