Apostatin-1 [2559703-06-7]

MedChem Express

Apostatin-1 [2559703-06-7]

10

2559703-06-7

Research Use Only

99.84

C19H27N3OS

345.50

Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 microM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, alpha-synuclein, or huntingtin[1].

O=C(NC1CCCCCC1)C(SC2=NCCN2C)C3=CC=CC=C3

-20°C,2°C to 8°C

12352200