Apostatin-1

AbMole BioScience

Apostatin-1

9

2559703-06-7

Chemical

Research Use Only

C19H27N3OS

345.51

Apostatin-1 (Apt-1) is a new type of TRADD inhibitor. Apostatin 1 can bind to TRADD-N (KD=2.17 uM), and destroy the binding of Apostatin 1 to TRADD-C and TRAF2. Apostatin-1 regulates ubiquitination of RIPK1 and beclin 1. By activating autophagy in cells accumulated by mutated tau, alfa-synuclein or huntingtin, Apostatin 1 blocked apoptosis and restored homeostasis.

CN1CCN=C1SC(C(=O)NC2CCCCCC2)C3=CC=CC=C3

12352200