APS-2-79

MedChem Express

APS-2-79 [2002381-25-9]

10

2002381-25-9

Research Use Only

99.38

C23H21N3O3

387.43

APS-2-79 is a KSR -dependent MEK antagonist. APS-2-79 inhibits ATP biotin binding to KSR2 within the KSR2-MEK1 complexe with an IC 50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling [1] .

CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=NC=NC4=CC(OC)=C(OC)C=C43

-20°C,2°C to 8°C

12352200