APS-2-79 [2002381-25-9]

TargetMol Chemicals

APS-2-79 [2002381-25-9]

72

2002381-25-9

Chemical

Research Use Only

APS-2-79

C23H21N3O3

387.43

APS-2-79, a KSR-dependent MEK antagonist, disrupts ATP (biotin) binding within the KSR2-MEK1 complex, achieving an inhibitory concentration (IC50) of 120 nM. This action stabilizes the KSR inactive state and antagonizes oncogenic Ras-MAPK signaling.

3 years

COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3C)c2cc1OC

-20°C

12352200