Bio-Connect

ARHGEF18 antibody

GTX102223
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetARHGEF18
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Overview

  • Supplier
    GeneTex
  • Product Name
    ARHGEF18 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID23370
  • Target name
    ARHGEF18
  • Target description
    Rho/Rac guanine nucleotide exchange factor 18
  • Target synonyms
    114 kDa Rho-specific guanine nucleotide exchange factor; p114RhoGEF; P114-RhoGEF; rho guanine nucleotide exchange factor 18; Rho/Rac guanine nucleotide exchange factor (GEF) 18; Rho-specific guanine nucleotide exchange factor p114; RP78; SA-RhoGEF; septin-associated RhoGEF
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ6ZSZ5
  • Protein Name
    Rho guanine nucleotide exchange factor 18
  • Scientific Description
    Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly. Haas AJ et al., 2020 Jul 21, Cell Rep
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  • Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs. Lu A et al., 2018 Dec 17, Elife
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  • The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells. Itoh M et al., 2017 Nov 3, Oncotarget
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  • An apical MRCK-driven morphogenetic pathway controls epithelial polarity. Zihni C et al., 2017 Sep, Nat Cell Biol
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  • CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling. Loie E et al., 2015 Oct, Mol Cell Biol
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  • MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells. Yamamura S et al., 2012, PLoS One
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  • MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma. Yamamura S et al., 2012 Feb, Carcinogenesis
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  • Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H et al., 2011 Oct 17, J Cell Biol
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