ARMER antibody

GeneTex

ARMER antibody

9

WB: 0.5 - 2 microg/mL. IHC-P: 2 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ARL6IP1

ARL6 interacting reticulophagy regulator 1

AIP1, ARL6IP, ARMER, SPG61, ADP-ribosylation factor-like protein 6-interacting protein 1, ADP ribosylation factor like GTPase 6 interacting protein 1, ADP-ribosylation factor GTPase 6 interacting protein 1, ADP-ribosylation factor-like 6 interacting protein 1, ARF like GTPase 6 interacting protein 1, ARL-6-interacting protein 1, aip-1, apoptotic regulator in the membrane of the endoplasmic reticulum

Rabbit

IgG

ADP-ribosylation factor-like protein 6-interacting protein 1

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

-20°C or -80°C,2°C to 8°C

12352203