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ARV-471 [2229711-68-4]

ARV-471 [2229711-68-4]

T39710
TargetMol Chemicals
CAS Number2229711-68-4
DownloadMSDS
Product group Chemicals
Estimated Purity99.85%
Molecular Weight723.9
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    ARV-471 [2229711-68-4]
  • Delivery Days Customer
    4
  • CAS Number
    2229711-68-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    ARV-471
  • Estimated Purity
    99.85%
  • Molecular Formula
    C45H49N5O4
  • Molecular Weight
    723.9
  • Scientific Description
    Vepdegestrant (ARV-471) is an estrogen receptor (ER) alpha PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
  • Shelf life instruction
    3 years
  • SMILES
    OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5)=CC1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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