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Vepdegestrant (ARV-471)

M21158
AbMole BioScience
CAS Number2229711-68-4
Product group Chemicals
Molecular Weight723.9
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Vepdegestrant (ARV-471)
  • Delivery Days Customer
    9
  • CAS Number
    2229711-68-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C45H49N5O4
  • Molecular Weight
    723.9
  • Scientific Description
    Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer.ARV-471 is a heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes.ARV-471 causes ubiquitination and subsequent degradation of the estrogen receptor via the proteasome.ARV-471 potently degrades ER-positive The ER in breast cancer cell lines is potently degraded by ARV-471 with a DC50 value of approximately 2 nM.
  • Storage Instruction
    -20°C, protect from light, dry, sealed
  • UNSPSC
    12352200