ARV-766

AbMole BioScience

ARV-766

9

2750830-09-0

Chemical

Research Use Only

C45H54FN7O6

807.95

ARV-766 is an orally active and potent proteolysis targeting chimera (PROTAC) protein degrader. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations. ARV-766 has the potential to be first- and best-in class PROTAC AR degrader in mCRPC.

COC1=C(C=CC(=C1)OC2C(C)(C)C(NC(=O)C3=CC=C(C=C3)N4CCC(CC4)CN5CCN(CC5)C6=CC(=C(C=C6)C(=O)NC7CCC(=O)NC7=O)F)C2(C)C)C#N

4°C, dry, sealed

12352200