ARV-766

Biorbyt

ARV-766

10

Research Use Only

C45H54FN7O6

807.9519744

ARV-766 is an orally active and potent proteolysis targeting chimera (PROTAC) protein degrader. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations[1].

C(N[C@H]1CCC(=O)NC1=O)(=O)C1=CC=C(N2CCN(CC3CCN(C4=CC=C(C(N[C@@H]5C(C)(C)[C@@H](OC6=CC=C(C#N)C(OC)=C6)C5(C)C)=O)C=C4)CC3)CC2)C=C1F

12352200