AS2863619

MedChem Express

AS2863619 [2241300-51-4]

10

2241300-51-4

Research Use Only

99.94

C16H14Cl2N8O

405.24

AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3 + regulatory T (T reg ) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC 50 s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19 , which consequently activates the Foxp3 gene [1] .

NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5.[H]Cl.[H]Cl

2°C to 8°C

12352200