ASIC1 Antibody

Cusabio

ASIC1 Antibody

20

ImmunoFluorescence, Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

ASIC1

acid sensing ion channel subunit 1

ACCN2, ASIC, BNaC2, acid-sensing ion channel 1, Cation channel, amiloride-sensitive, neuronal, 2, acid sensing (proton gated) ion channel 1, acid-sensing ion channel 1a protein, amiloride-sensitive cation channel 2, neuronal, brain sodium channel 2

Rabbit

IgG

Acid-sensing ion channel 1

Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Human, Mouse

-20°C or -80°C

41116161