ATG3 Antibody, HRP conjugated
CSB-PA002288HB01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetATG3
Overview
- SupplierCusabio
- Product NameATG3 Antibody, HRP conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateHRP
- Gene ID64422
- Target nameATG3
- Target descriptionautophagy related 3
- Target synonyms2610016C12Rik; APG3; APG3 autophagy 3-like; APG3L; APG3-LIKE; ATG3 autophagy related 3 homolog; autophagy-related protein 3; hApg3; PC3-96; ubiquitin-like-conjugating enzyme ATG3
- HostRabbit
- IsotypeIgG
- Protein IDQ9NT62
- Protein NameUbiquitin-like-conjugating enzyme ATG3
- Scientific DescriptionE2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203