ATG4B Antibody, Biotin conjugated

Cusabio

ATG4B Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

ATG4B

autophagy related 4B cysteine peptidase

APG4B, AUTL1, HsAPG4B, cysteine protease ATG4B, APG4 autophagy 4 homolog B, ATG4 autophagy related 4 homolog B, AUT-like 1 cysteine endopeptidase, autophagin-1, autophagy-related cysteine endopeptidase 1, autophagy-related protein 4 homolog B, hAPG4B

Rabbit

IgG

Cysteine protease ATG4B

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Human

-20°C or -80°C

41116161