ATM Inhibitor-1 [2135639-94-8]

MedChem Express

ATM Inhibitor-1 [2135639-94-8]

10

2135639-94-8

Research Use Only

C27H36N6O3

492.61

ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 microM), DNAPK (IC50, 2.8 microM), PI3Kalpha (IC50, 3.8 microM), PI3Kbeta (IC50, 10.3 microM), PI3Kgamma (IC50, 3 microM) and PI3Kdelta (IC50, 0.73 microM). ATM Inhibitor-1 exhibits anti-tumor activity[1].

C[C@@H](C1CCOCC1)NC2=C(C(NC)=O)N=NC3=CC=C(C4=CC=C(OCCCN(C)C)N=C4)C=C32

12352200