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Autotaxin antibody

GTX106209
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetENPP2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Autotaxin antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.13 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5168
  • Target name
    ENPP2
  • Target description
    ectonucleotide pyrophosphatase/phosphodiesterase 2
  • Target synonyms
    ATX; ATX-X; AUTOTAXIN; autotaxin-t; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; extracellular lysophospholipase D; LysoPLD; NPP2; PD-IALPHA; PDNP2; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13822
  • Protein Name
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
  • Scientific Description
    The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5 end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion. Geng H et al., 2021 Mar 1, Am J Physiol Renal Physiol
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  • Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis. Wang Z et al., 2020 Dec, J Mol Med (Berl)
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  • Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro. Tsukahara T et al., 2020 Feb 28, Sci Rep
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  • High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells. Huang YL et al., 2018, Cell Physiol Biochem
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  • Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors. Pleli T et al., 2018, Cell Physiol Biochem
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  • Association of autotaxin and lysophosphatidic acid receptor 3 with aggressiveness of human breast carcinoma. Popnikolov NK et al., 2012 Dec, Tumour Biol
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