Autotaxin antibody
GTX106209
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetENPP2
Overview
- SupplierGeneTex
- Product NameAutotaxin antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.13 mg/ml
- ConjugateUnconjugated
- Gene ID5168
- Target nameENPP2
- Target descriptionectonucleotide pyrophosphatase/phosphodiesterase 2
- Target synonymsATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2, autotaxin, E-NPP 2, autotaxin-t, ectonucleotide pyrophosphatase/phosphodiesterase family member 2, extracellular lysophospholipase D, phosphodiesterase I/nucleotide pyrophosphatase 2, plasma lysophospholipase D
- HostRabbit
- IsotypeIgG
- Protein IDQ13822
- Protein NameAutotaxin
- Scientific DescriptionThe protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5 end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Geng H, Lan R, Liu Y, et al. Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion. Am J Physiol Renal Physiol. 2021,320(3):F359-F374. doi: 10.1152/ajprenal.00494.2020Read this paper
- Wang Z, Shi W, Tian D, et al. Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis. J Mol Med (Berl). 2020,98(12):1781-1794. doi: 10.1007/s00109-020-01997-6Read this paper
- Tsukahara T, Haniu H, Uemura T, et al. Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro. Sci Rep. 2020,10(1):3748. doi: 10.1038/s41598-020-60781-1Read this paper
- Huang YL, Lin YC, Lin CC, et al. High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells. Cell Physiol Biochem. 2018,50(2):597-611. doi: 10.1159/000494177Read this paper
- Pleli T, Mondorf A, Ferreiros N, et al. Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors. Cell Physiol Biochem. 2018,45(6):2516-2528. doi: 10.1159/000488270Read this paper
- Popnikolov NK, Dalwadi BH, Thomas JD, et al. Association of autotaxin and lysophosphatidic acid receptor 3 with aggressiveness of human breast carcinoma. Tumour Biol. 2012,33(6):2237-43. doi: 10.1007/s13277-012-0485-1Read this paper






