Avadomide

MedChem Express

Avadomide [1015474-32-4]

5

1015474-32-4

99.37

C14H14N4O3

286.291

Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-kappaB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities [1] [2] [3] .

O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O

-20°C,2°C to 8°C

12352200