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ProductsBack/Avarol [55303-98-5]
Chemical Structure
Chemical Structure
Chemical Structure

Avarol [55303-98-5]

Research Use Only
AG-CN2-0044
AdipoGen Life Sciences
CAS Number55303-98-5
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight314.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Avarol [55303-98-5]
  • Delivery Days Customer
    10
  • CAS Number
    55303-98-5
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C21H30O2
  • Molecular Weight
    314.5
  • Scientific Description
    Antibacterial against selected Gram-positive strains, antifungal [1, 6]. Anticancer compound [2]. Antileukemic [4, 5, 8, 9]. Antimitotic agent [3]. Antiviral compound [7, 8, 14]. Inhibits HIV activity [7, 8, 14]. Anti-inflammatory [10, 12]. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor [10, 12]. Modulator of superoxide dismutase and glutathione peroxidase [11]. Platelet aggregation inhibitor [13]. Anti-psoriatic [15, 17], mediated by inhibition of TNF-alpha generation and NF-kappaB activation [18, 19]. Reviews [16, 20]. - Chemical. CAS: 55303-98-5. Formula: C21H30O2. MW: 314.5. Isolated from sponge Dysidea avara. Antibacterial against selected Gram-positive strains, antifungal. Anticancer compound. Antileukemic. Antimitotic agent. Antiviral compound. Inhibits HIV activity. Anti-inflammatory. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor. Modulator of superoxide dismutase and glutathione peroxidase. Platelet aggregation inhibitor. Anti-psoriatic, mediated by inhibition of TNF-alpha generation and NF-kappaB activation. Reviews.
  • SMILES
    [H][C@@]12CCC=C(C)[C@@]1(C)CC[C@H](C)[C@@]2(C)CC1=CC(O)=CC=C1O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Antimicrobial activity of avarol, a sesquiterpenoid hydroquinone from the marine sponge, Dysidea avara: L. Cariello, et al.; Comp. Biochem. Physiol. B. 71, 281 (1982)
  • Avarol, a cytostatically active compound from the marine sponge Dysidea avara: W.E. Müller, et al.; Comp. Biochem. Physiol. C. 80, 47 (1985)
  • Inhibition of mitosis by avarol, a natural product isolated from the sponge Dysidea avara: W.E. Müller, et al.; Basic Appl. Histochem. 29, 321 (1985)
  • Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo: W.E. Müller, et al.; Cancer Res. 45, 4822 (1985)
  • Antimutagenic activity of the novel antileukemic agents, avarone and avarol: B. Kurelec, et al.; Mutat. Res. 144, 63 (1985)
  • Antibacterial and antifungal activity of Avarone and Avarol: G. Seibert, et al.; Zentralbl. Bakteriol. Mikrobiol. Hyg. A. 260, 379 (1985)
  • Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone: P.S. Sarin, et al.; J. Natl. Cancer Inst. 78, 663 (1987)
  • Influence of the antileukemic and anti-human immunodeficiency virus agent avarol on selected immune responses in vitro and in vivo: W.E. Müller, et al.; Biochem. Pharmacol. 36, 1489 (1987)
  • Avarol-induced DNA strand breakage in vitro and in Friend erythroleukemia cells: W.E. Müller, et al.; Cancer Res. 47, 6565 (1987)
  • Induction of gamma-interferon by avarol in human peripheral blood lymphocytes: R. Voth, et al.; Jpn. J. Cancer Res. 79, 647 (1988)