Chemical Structure
Avarol [55303-98-5]
AG-CN2-0044
Overview
- SupplierAdipoGen Life Sciences
- Product NameAvarol
- Delivery Days Customer10
- CAS Number55303-98-5
- CertificationResearch Use Only
- Estimated Purity>97%
- Molecular FormulaC21H30O2
- Molecular Weight314.5
- Scientific DescriptionAntibacterial against selected Gram-positive strains, antifungal [1, 6]. Anticancer compound [2]. Antileukemic [4, 5, 8, 9]. Antimitotic agent [3]. Antiviral compound [7, 8, 14]. Inhibits HIV activity [7, 8, 14]. Anti-inflammatory [10, 12]. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor [10, 12]. Modulator of superoxide dismutase and glutathione peroxidase [11]. Platelet aggregation inhibitor [13]. Anti-psoriatic [15, 17], mediated by inhibition of TNF-alpha generation and NF-kappaB activation [18, 19]. Reviews [16, 20]. - Chemical. CAS: 55303-98-5. Formula: C21H30O2. MW: 314.5. Isolated from sponge Dysidea avara. Antibacterial against selected Gram-positive strains, antifungal. Anticancer compound. Antileukemic. Antimitotic agent. Antiviral compound. Inhibits HIV activity. Anti-inflammatory. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor. Modulator of superoxide dismutase and glutathione peroxidase. Platelet aggregation inhibitor. Anti-psoriatic, mediated by inhibition of TNF-alpha generation and NF-kappaB activation. Reviews.
- SMILES[H][C@@]12CCC=C(C)[C@@]1(C)CC[C@H](C)[C@@]2(C)CC1=CC(O)=CC=C1O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Antimicrobial activity of avarol, a sesquiterpenoid hydroquinone from the marine sponge, Dysidea avara: L. Cariello, et al.; Comp. Biochem. Physiol. B. 71, 281 (1982)
- Avarol, a cytostatically active compound from the marine sponge Dysidea avara: W.E. Müller, et al.; Comp. Biochem. Physiol. C. 80, 47 (1985)
- Inhibition of mitosis by avarol, a natural product isolated from the sponge Dysidea avara: W.E. Müller, et al.; Basic Appl. Histochem. 29, 321 (1985)
- Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo: W.E. Müller, et al.; Cancer Res. 45, 4822 (1985)
- Antimutagenic activity of the novel antileukemic agents, avarone and avarol: B. Kurelec, et al.; Mutat. Res. 144, 63 (1985)
- Antibacterial and antifungal activity of Avarone and Avarol: G. Seibert, et al.; Zentralbl. Bakteriol. Mikrobiol. Hyg. A. 260, 379 (1985)
- Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone: P.S. Sarin, et al.; J. Natl. Cancer Inst. 78, 663 (1987)
- Influence of the antileukemic and anti-human immunodeficiency virus agent avarol on selected immune responses in vitro and in vivo: W.E. Müller, et al.; Biochem. Pharmacol. 36, 1489 (1987)
- Avarol-induced DNA strand breakage in vitro and in Friend erythroleukemia cells: W.E. Müller, et al.; Cancer Res. 47, 6565 (1987)
- Induction of gamma-interferon by avarol in human peripheral blood lymphocytes: R. Voth, et al.; Jpn. J. Cancer Res. 79, 647 (1988)