Axin 2 antibody [N2C2], Internal
GTX105442
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetAXIN2
Overview
- SupplierGeneTex
- Product NameAxin 2 antibody [N2C2], Internal
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID8313
- Target nameAXIN2
- Target descriptionaxin 2
- Target synonymsAXIL; axin-2; axin-like protein; axis inhibition protein 2; conductin; ODCRCS
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y2T1
- Protein NameAxin-2
- Scientific DescriptionThe Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells. Hsu TH et al., 2015 May, Cell Death DifferRead more