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ProductsBack/AXIN1 Antibody

Immunohistochemistry analysis of human testis tissue using CSB-PA517675LA01HU at dilution of 1:100

Immunohistochemistry analysis of human testis tissue using CSB-PA517675LA01HU at dilution of 1:100

Immunohistochemistry analysis of human testis tissue using CSB-PA517675LA01HU at dilution of 1:100

AXIN1 Antibody

CSB-PA517675LA01HU

ApplicationsELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetAXIN1

Overview

Supplier
Cusabio
Product Name
AXIN1 Antibody
Delivery Days Customer
20
Applications
ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID8312
Target name
AXIN1
Target description
axin 1
Target synonyms
AXIN, CMDOH, PPP1R49, axin-1, axis inhibition protein 1, axis inhibitor 1, fused, mouse, homolog of, protein phosphatase 1, regulatory subunit 49
Host
Rabbit
Isotype
IgG
Protein IDO15169
Protein Name
Axin-1
Scientific Description
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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