AY 9944

MedChem Express

AY 9944 [366-93-8]

10

366-93-8

Research Use Only

99.67

C22H30Cl4N2

464.30

AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol delta7-reductase (DHCR7) enzyme with an IC 50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol delta7-delta8 isomerase, which causes the accumulation of cholest-8-en-3beta-ol [1] [2] [3] .

ClC(C=CC=C1)=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C=CC=C3)Cl.[H]Cl.[H]Cl

2°C to 8°C

12352200