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AY 9944

T14362
TargetMol Chemicals
CAS Number366-93-8
Product group Chemicals
Molecular Weight464.3
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    AY 9944
  • Delivery Days Customer
    4
  • CAS Number
    366-93-8
  • Category Supplier
    Chemical
  • Chemical Name
    AY 9944
  • Molecular Formula
    C22H30Cl4N2
  • Molecular Weight
    464.3
  • Scientific Description
    AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3bèta-ol[1][2][3]. AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
  • Shelf life instruction
    3 years
  • SMILES
    ClC(C=CC=C1)=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C=CC=C3)Cl.[H]Cl.[H]Cl
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Dvornik D, et al. Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol delta 7-reductase, on serum and tissue lipids in the rat. J Lipid Res. 1968 Sep;9(5):587-95.
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