AZ5104

AbMole BioScience

AZ5104

9

1421373-98-9

Research Use Only

>99.0%

C27H31N7O2

485.58

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively.

COC1=C(NC2=NC=CC(=N2)C3=C[NH]C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C

12352200