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AZ9482 [1825345-33-2]

Research Use Only
SYN-3046
SYNkinase
CAS Number1825345-33-2
Product group Chemicals
Estimated Purity>95%
Molecular Weight450.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    AZ9482 [1825345-33-2]
  • Delivery Days Customer
    10
  • CAS Number
    1825345-33-2
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C26H22N6O2
  • Molecular Weight
    450.5
  • Scientific Description
    AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9nM enzyme inhibitor of tankyrase 1 (TNKS1). - Chemical. CAS: 1825345-33-2. Formula: C26H22N6O2. MW: 450.5. AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9nM enzyme inhibitor of tankyrase 1 (TNKS1).
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000